how to hack and patch your andriod games and apps

Lucky Patcher is an app that gives you real control over the permissions you give to the app installed on your andriod device
and you can hack your andriod games and apps. Lucky patcher lets you take control of the apps installed
on your andriod and enjoy almost all feature in the rooted device

To hack your andriod games or apps follow this steps

step 1.   Open your lucky patcher. to download this app click here.
step 2.   select apps or games
step 3.   then open menu of patches
step 4.   then click support patch for In App and LVL emulation
step 5.   select   
                  support patch for LVL emulation  and
                  support patch for IN APP emullation
step 6. Then applyit and waite for a minute to complete process
step 7. You will see percentage of luck and it is done and click on ok
step 8. Open Toogles Toolbar
step 9. enable google lisence verification emulation

step 10 And it is done and enjoy it..

don't be afraid to fail1

TOP 5 PLACE TO VISIT BEFORE LEAVING THIS WORLD

What better way to make the most of the life then travel? The world’s wonders are too vast to see everything in one life time, but if you are looking to spice things up and see some earth’s finest landmarks, you can start by knocking a couple of list.

Here are Top 5 places you must see before you die, because life is just too dang short not to live.

5. Miami, Florida

Florida is nicknamed The Sunshine, so except beautiful weather, awesome beaches and some of the most stunning parks you’ve ever seen.

One of the most vibrant cities in the USA, Miami is the best known for its Latin culture and sizzling nightlife located in Southeastern Florida off the coast of Atlantic Ocean, Miami is also a major port city managing the world’s largest number of passengers cruise ship. Attracting tourists from all over the planet, Miami’s is a melting pot of ethnic cultures with a wide array of exciting attraction and activities. One of the Miami’s main advantages is its sunny beaches that range from family, friendly to party scenes. Across the bay from Miami on a barrier island is Miami Beach, known for the Art Deco architecture and glamorous South Beach.

4. Mount Fuji, Japan

Mount Fuji is the Japan’s highest peak and also one of its most scared locations. The popular spot for artists and tourists. The perfectly symmetrical snow topped volcano is perched before Lake Kawaguchi making up one of the world’s most recognizable natural destinations. Embrace the culture and cuisine of the Japan in the country’s most traveled region. Just a short trip away from the Tokyo, Mount Fuji encompasses appeal for nature seekers and city travelers alike. There may be no prettier time to visit Mount Fuji than in the spring time, when cherry blossom trees are in full bloom around the Fuji five lakes.

Also make sure to check out one of many surrounding shrines to experience amazing architecture and a scared cultural experience.

3. Wengen, Switzerland

Wengen is a village in the Bernese oberland in the canton of Bern, located in central Switzerland. A special cultural feature of Wengen is so called “Pfeifende Lurch” (German for “whistling amphibian”). It is a legendary creature from myths and tales that only exists in Wengen.

In this village, Cars of any kind have been banned for more than 100 year. The town is tucked away between alpine mountains and lush, grassy hills in every direction while the air is crisp and clean, un-polluted by the diesel and muck of a city. So, this is the popular tourist spot also has some of the world’s finest modern ski racing and Alpine skiing spots.

2. Kauai, Hawaii

If there is heaven in the earth, you will hardly find a more beautiful location than Kauai, Hawaii. Relaxing and Pristine Kauai (The Garden Island) Is the least commercially developed of the Hawaiian islands. Nicknamed The Garden Island, Kauai is literally covered in green, while each of Hawaii’s eight island is stunning. Kauai houses geologic spectacles like the cliff along the Nepali and the Waimea Canyon in the heart of the island.

If simply relaxing in the tropical Hawaiian sun isn’t enough travel through the high hills of the Kauai in style. In Kauai some beaches have pools and some are perfect for all kinds of water spots. Also make sure to grab a snorkel and explore the crystal clear water surrounding the island and teeming with tropical fish.

1.    Nepal

       Nepal is the country full of natural beauties. Not only 

the huge mountains, we can also see various lakes, rivers, caves which are the inhabitant for varieties of the wildlife and birds.

Nepal nature tour is one of the best tour to explore the natural beauty of Nepaland in the world. Nepal is

 known as the naturally beautiful country, and it is the best choice for Nature lovers, and best place in the world to observe the natural beauty and feel peace in 

the land of lord Buddha

Researchers create 'mini-brains' in lab to study neurological diseases

Researchers at the Johns Hopkins Bloomberg School of Public Health say they have developed tiny "mini-brains" made up of many of the neurons and cells of the human brain -- and even some of its functionality -- and which can be replicated on a large scale.

The researchers say that the creation of these "mini-brains," which will be discussed at the American Association for the Advancement of Science conference in Washington, DC on Feb. 12 at a press briefing and in a session on Feb. 13, could dramatically change how new drugs are tested for effectiveness and safety, taking the place of the hundreds of thousands of animals used for neurological scientific research in the United States. Performing research using these three-dimensional "mini-brains" -- balls of brain cells that grow and form brain-like structures on their own over the course of eight weeks -- should be superior to studying mice and rats because they are derived from human cells instead of rodents, they say.

"Ninety-five percent of drugs that look promising when tested in animal models fail once they are tested in humans at great expense of time and money," says study leader Thomas Hartung, MD, PhD, the Doerenkamp-Zbinden Professor and Chair for Evidence-based Toxicology at the Bloomberg School. "While rodent models have been useful, we are not 150-pound rats. And even though we are not balls of cells either, you can often get much better information from these balls of cells than from rodents.

"We believe that the future of brain research will include less reliance on animals, more reliance on human, cell-based models."

Hartung and his colleagues created the brains using what are known as induced pluripotent stem cells (iPSCs). These are adult cells that have been genetically reprogrammed to an embryonic stem cell-like state and then are stimulated to grow into brain cells. Cells from the skin of several healthy adults were used to create the mini-brains, but Hartung says that cells from people with certain genetic traits or certain diseases can be used to create brains to study various types of pharmaceuticals. He says the brains can be used to study Alzheimer's disease, Parkinson's disease, multiple sclerosis and even autism. Projects to study viral infections, trauma and stroke have been started.

Hartung's mini-brains are very small -- at 350 micrometers in diameter, or about the size of the eye of a housefly, they are just visible to the human eye -- and hundreds to thousands of exact copies can be produced in each batch. One hundred of them can grow easily in the same petri dish in the lab. After cultivating the mini-brains for about two months, the brains developed four types of neurons and two types of support cells: astrocytes and oligodendrocytes, the latter of which go on to create myelin, which insulates the neuron's axons and allows them to communicate faster.

The researchers could watch the myelin developing and could see it begin to sheath the axons. The brains even showed spontaneous electrophysiological activity, which could be recorded with electrodes, similar to an electroencephalogram, also known as EEG. To test them, the researchers placed a mini-brain on an array of electrodes and listened to the spontaneous electrical communication of the neurons as test drugs were added.

"We don't have the first brain model nor are we claiming to have the best one," says Hartung, who also directs the School's Center for Alternatives to Animal Testing.

"But this is the most standardized one. And when testing drugs, it is imperative that the cells being studied are as similar as possible to ensure the most comparable and accurate results."

Hartung is applying for a patent for the mini-brains and is also developing a commercial entity called ORGANOME to produce them. He hopes production can begin in 2016. He says they are easily reproducible and hopes to see them used by scientists in as many labs as possible. "Only when we can have brain models like this in any lab at any time will we be able to replace animal testing on a large scale," he says.

The work was supported by the National Institutes of Health's National Center for Advancing Translational Sciences (U18TR000547), the Alternatives Research & Development Foundation and the Bart McLean Fund for Neuroimmunology Research/Project Restore.

Other researchers involved in the project include David Pamies; Paula Barreras, Katharina Block; Georgia Makri; Anupama Kumar; Daphne Wiersma; Lena Smirnova; Che Zang; Joseph Bressler; Kimberly M. Christian; Georgina Harris; Guo-li Ming; Cindy J. Berlincke; Kelly Kyro; Hongjun Song; Carlos Pardo; Thomas Hartung and Helena T. Hogberg.

GRAVITATIONAL WAVE FINALLY DETECTED

For the first time, scientists have observed ripples in the fabric of spacetime called gravitational waves, arriving at Earth from a cataclysmic event in the distant universe. This confirms a major prediction of Albert Einstein's 1915 general theory of relativity and opens an unprecedented new window onto the cosmos.

Gravitational waves carry information about their dramatic origins and about the nature of gravity that cannot otherwise be obtained. Physicists have concluded that the detected gravitational waves were produced during the final fraction of a second of the merger of two black holes to produce a single, more massive spinning black hole. This collision of two black holes had been predicted but never observed.

The gravitational waves were detected on September 14, 2015 at 5:51 a.m. Eastern Daylight Time (09:51 UTC) by both of the twin Laser Interferometer Gravitational-wave Observatory (LIGO) detectors, located in Livingston, Louisiana, and Hanford, Washington, USA. The LIGO Observatories are funded by the National Science Foundation (NSF), and were conceived, built, and are operated by Caltech and MIT. The discovery, accepted for publication in the journal Physical Review Letters, was made by the LIGO Scientific Collaboration (which includes the GEO Collaboration and the Australian Consortium for Interferometric Gravitational Astronomy) and the Virgo Collaboration using data from the two LIGO detectors.

Based on the observed signals, LIGO scientists estimate that the black holes for this event were about 29 and 36 times the mass of the sun, and the event took place 1.3 billion years ago. About 3 times the mass of the sun was converted into gravitational waves in a fraction of a second -- with a peak power output about 50 times that of the whole visible universe. By looking at the time of arrival of the signals -- the detector in Livingston recorded the event 7 milliseconds before the detector in Hanford -- scientists can say that the source was located in the Southern Hemisphere.

According to general relativity, a pair of black holes orbiting around each other lose energy through the emission of gravitational waves, causing them to gradually approach each other over billions of years, and then much more quickly in the final minutes. During the final fraction of a second, the two black holes collide into each other at nearly one-half the speed of light and form a single more massive black hole, converting a portion of the combined black holes' mass to energy, according to Einstein's formula E=mc². This energy is emitted as a final strong burst of gravitational waves. It is these gravitational waves that LIGO has observed.

The existence of gravitational waves was first demonstrated in the 1970s and 80s by Joseph Taylor, Jr., and colleagues. Taylor and Russell Hulse discovered in 1974 a binary system composed of a pulsar in orbit around a neutron star. Taylor and Joel M. Weisberg in 1982 found that the orbit of the pulsar was slowly shrinking over time because of the release of energy in the form of gravitational waves. For discovering the pulsar and showing that it would make possible this particular gravitational wave measurement, Hulse and Taylor were awarded the Nobel Prize in Physics in 1993.

The new LIGO discovery is the first observation of gravitational waves themselves, made by measuring the tiny disturbances the waves make to space and time as they pass through Earth.

"Our observation of gravitational waves accomplishes an ambitious goal set out over 5 decades ago to directly detect this elusive phenomenon and better understand the universe, and, fittingly, fulfills Einstein's legacy on the 100th anniversary of his general theory of relativity," says Caltech's David H. Reitze, executive director of the LIGO Laboratory.

The discovery was made possible by the enhanced capabilities of Advanced LIGO, a major upgrade that increases the sensitivity of the instruments compared to the first generation LIGO detectors, enabling a large increase in the volume of the universe probed -- and the discovery of gravitational waves during its first observation run. The US National Science Foundation leads in financial support for Advanced LIGO. Funding organizations in Germany (Max Planck Society), the U.K. (Science and Technology Facilities Council, STFC) and Australia (Australian Research Council) also have made significant commitments to the project. Several of the key technologies that made Advanced LIGO so much more sensitive have been developed and tested by the German UK GEO collaboration. Significant computer resources have been contributed by the AEI Hannover Atlas Cluster, the LIGO Laboratory, Syracuse University, and the University of Wisconsin- Milwaukee. Several universities designed, built, and tested key components for Advanced LIGO: The Australian National University, the University of Adelaide, the University of Florida, Stanford University, Columbia University of the City of New York, and Louisiana State University.

"In 1992, when LIGO's initial funding was approved, it represented the biggest investment the NSF had ever made," says France Córdova, NSF director. "It was a big risk. But the National Science Foundation is the agency that takes these kinds of risks. We support fundamental science and engineering at a point in the road to discovery where that path is anything but clear. We fund trailblazers. It's why the U.S. continues to be a global leader in advancing knowledge."

LIGO research is carried out by the LIGO Scientific Collaboration (LSC), a group of more than 1000 scientists from universities around the United States and in 14 other countries. More than 90 universities and research institutes in the LSC develop detector technology and analyze data; approximately 250 students are strong contributing members of the collaboration. The LSC detector network includes the LIGO interferometers and the GEO600 detector. The GEO team includes scientists at the Max Planck Institute for Gravitational Physics (Albert Einstein Institute, AEI), Leibniz Universität Hannover, along with partners at the University of Glasgow, Cardiff University, the University of Birmingham, other universities in the United Kingdom, and the University of the Balearic Islands in Spain.

"This detection is the beginning of a new era: The field of gravitational wave astronomy is now a reality," says Gabriela González, LSC spokesperson and professor of physics and astronomy at Louisiana State University.

LIGO was originally proposed as a means of detecting these gravitational waves in the 1980s by Rainer Weiss, professor of physics, emeritus, from MIT; Kip Thorne, Caltech's Richard P. Feynman Professor of Theoretical Physics, emeritus; and Ronald Drever, professor of physics, emeritus, also from Caltech.

"The description of this observation is beautifully described in the Einstein theory of general relativity formulated 100 years ago and comprises the first test of the theory in strong gravitation. It would have been wonderful to watch Einstein's face had we been able to tell him," says Weiss.

"With this discovery, we humans are embarking on a marvelous new quest: the quest to explore the warped side of the universe -- objects and phenomena that are made from warped spacetime. Colliding black holes and gravitational waves are our first beautiful examples," says Thorne.

Virgo research is carried out by the Virgo Collaboration, consisting of more than 250 physicists and engineers belonging to 19 different European research groups: 6 from Centre National de la Recherche Scientifique (CNRS) in France; 8 from the Istituto Nazionale di Fisica Nucleare (INFN) in Italy; 2 in The Netherlands with Nikhef; the Wigner RCP in Hungary; the POLGRAW group in Poland; and the European Gravitational Observatory (EGO), the laboratory hosting the Virgo detector near Pisa in Italy.

Fulvio Ricci, Virgo Spokesperson, notes that, "This is a significant milestone for physics, but more importantly merely the start of many new and exciting astrophysical discoveries to come with LIGO and Virgo."

Bruce Allen, managing director of the Max Planck Institute for Gravitational Physics (Albert Einstein Institute), adds, "Einstein thought gravitational waves were too weak to detect, and didn't believe in black holes. But I don't think he'd have minded being wrong!"

"The Advanced LIGO detectors are a tour de force of science and technology, made possible by a truly exceptional international team of technicians, engineers, and scientists," says David Shoemaker of MIT, the project leader for Advanced LIGO. "We are very proud that we finished this NSF-funded project on time and on budget."

At each observatory, the two-and-a-half-mile (4-km) long L-shaped LIGO interferometer uses laser light split into two beams that travel back and forth down the arms (four-foot diameter tubes kept under a near-perfect vacuum). The beams are used to monitor the distance between mirrors precisely positioned at the ends of the arms. According to Einstein's theory, the distance between the mirrors will change by an infinitesimal amount when a gravitational wave passes by the detector. A change in the lengths of the arms smaller than one-ten-thousandth the diameter of a proton (10^-19 meter) can be detected.

"To make this fantastic milestone possible took a global collaboration of scientists -- laser and suspension technology developed for our GEO600 detector was used to help make Advanced LIGO the most sophisticated gravitational wave detector ever created," says Sheila Rowan, professor of physics and astronomy at the University of Glasgow.

Independent and widely separated observatories are necessary to determine the direction of the event causing the gravitational waves, and also to verify that the signals come from space and are not from some other local phenomenon.

Toward this end, the LIGO Laboratory is working closely with scientists in India at the Inter-University Centre for Astronomy and Astrophysics, the Raja Ramanna Centre for Advanced Technology, and the Institute for Plasma to establish a third Advanced LIGO detector on the Indian subcontinent. Awaiting approval by the government of India, it could be operational early in the next decade. The additional detector will greatly improve the ability of the global detector network to localize gravitational-wave sources.